Screening bioactive components affecting the capacity of bile acid binding and pancreatic lipase inhibitory activity
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چکیده
منابع مشابه
Inhibitory Effect of Ferula persica, Ginkgo biloba, Nelumbo nucifera, and Dicyclomine on the Activity of Pancreatic Lipase
Background and purpose: Pancreatic lipase is a major digestive enzyme in digestion and absorption of fats. Inhibition of the pancreatic lipase activity has always been one of the goals of researchers to control obesity and related disorders. Current inhibitory agents have several side effects. The aim of this study was to investigate the inhibitory effect of Ferula persica, Ginkgo biloba, Nel...
متن کاملBinding of bile salts to pancreatic colipase and lipase.
The binding of conjugated bile salts to pancreatic colipase and lipase has been studied by equilibrium dialysis and gel filtration. The results indicate that at physiological ionic strength and pH, conjugated bile salts bind as micelles to colipase: 12-15 moles/mole of colipase for the dihydroxy conjugates and 2-4 for the trihydroxy conjugates. No binding of bile salt takes place from monomeric...
متن کاملInteractions of pancreatic lipase with bile salts and dodecyl sulfate.
Sodium dodecyl sulfate (SDS) binds to pancreatic lipase in a cooperative manner up to about 200 moles/mole of protein. This binding in a rapid and irreversible inactivation of lipase. Bile salts under certain conditions prevent SDS inactivation of lipase when both detergents are present together. Under these conditions bile salts also prevent the binding of SDS to lipase. This effect is paralle...
متن کاملEvaluation of Antilipidperoxidation, Α-Amylase and Lipase Inhibitory Activity of Boswellia Ovalifoliolata Bal. Henry
The objective of the present study was to determine the antilipidperoxidation and in vitro α-amylase and lipase inhibitory activity of the Boswellia ovalifoliolata Bal Henry (BOB) extract. The polyphenolic compounds, flavonoids, and tannins content of the extracts were estimated by spectrophotometry. Antioxidant activity on goat liver lipid peroxidation and linoleic acid was d...
متن کاملImpact of dry solids and bile acid concentrations on bile acid binding capacity of extruded oat cereals.
Extruded breakfast cereals (EBC), processed from two oat lines, N979-5-2-4 (N979) and "Jim", with beta-glucan concentrations of 8.7 and 4.9%, respectively, were used to determine the impact of dry solids (DS) and bile acid (BA) concentrations on in vitro BA binding efficiency. A full fractional factorial design with levels for BA concentrations of 0.20, 0.47, 0.95, 2.37, and 4.73 micromol/g of ...
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ژورنال
عنوان ژورنال: Applied Biological Chemistry
سال: 2016
ISSN: 2468-0834,2468-0842
DOI: 10.1007/s13765-016-0184-5